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Filtered Search Results
Abcam Philanthoto x in-7,4 (PhT x -74), GluA1/GluA2 (formerly GluR1/2) inhibitor, 1MG
MW 507.5 Da, Purity >98%. A subtype-selective, use-dependent inhibitor of native AMPA receptors. Inhibits GluA1/A2 (formerly GluR1/2), with little activity at GluA2/A3 (formerly GluR2/3).
The product is subject to the following: Abcam Restricted Use Statement
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Cayman Chemical ANTIBODY C-87 5mg
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An inhibitor of TNF-α; binds to TNF-α; inhibits TNF-α-induced cytotoxicity (IC50 = 8.73 µM) in L-929 cells; reduces liver inflammation and injury, as well as increases survival, in a mouse model of LPS- and GalN-induced acute hepatitis at 12.5 mg/kg
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Cayman Chemical ANTIBODY MLS-573151 25mg
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A specific, cell permeable inhibitor of Cdc42 (IC50 = 2 μM); has no effect on other GTPases, including the related Rho family members RhoA, Rac1, and Rac2
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Cayman Chemical N-Desethyl VardenafIl 500UG
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A metabolite of vardenafil that is formed by the action of CYP3A4 and CYP3A5
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Medchemexpress LLC Azalamellarin N | 1809535-57-6 | 99.6% | 498.48 | 5 MG
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Azalamellarin N is an inhibitor of pyroptosis with varying inhibitory effects on different pyroptosis inducers. It inhibits pyroptosis by targeting molecules upstream of NLRP3 inflammasome activation, rather than directly targeting NLRP3 inflammasome components.
- Attenuates ATP- and nigericin-induced pyroptosis.
- Inhibits activation of the NLRP3 inflammasome.
- Strongly inhibited ATP- and nigericin-induced IL-1β release.
- Modestly inhibited R837-induced IL-1β release.
- Inhibited nigericin-induced cleavage of caspase-1.
- Suppressed ATP-induced oligomerization of ASC.
- Shows cytotoxicity in A549 cells with an IC50 of 0.0155 μM.
- Shows cytotoxicity in NCI-H1975 cells with an IC50 of 0.0019 μM.
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Medchemexpress LLC Heparan Sulfate 100MG | 9050-30-0
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Heparan Sulfate 100MG
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Cambridge Isotope Laboratories 25-HYDROXYVITAMIN D2 UNLABELED 100 UG/ML IN ETHANOL, 1 ML
25-HYDROXYVITAMIN D2 UNLABELED 100 UG/ML IN ETHANOL, 1 ML
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Cayman Chemical ANTIBODY-Menthol 10g
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A racemic mixture of the monoterpene alcohols (–)-menthol and (+)-menthol
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TARGETMOL CHEMICALS INC GAL-021 5MG
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Also available in 1mg 2mg 10mg 25mg 50mg 100mg 500mg and bulk. Please contact Fisher for quotes. GAL-021 an intravenous BKCa-channel blocker. purity: 99%
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Cayman Chemical ANTIBODY KendomycIn 500ug
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A macrolide from Streptomyces which displays potent cytotoxicity against several carcinoma cell lines (GI50 < 100 nM); also acts as an endothelin receptor antagonist and has antiosteoporotic activities
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Selleck Chemical LLC GNE-987-E1664-25MG
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GNE-987 is a BRD4-degradating PROTAC consisting of BRD4B1 and BRD4B2 (BRD4 bromodomains 1 and 2) and the VHL E3-ubiquitin ligase It exhibits BRD4 degradation activity with DC50 of 0 03 nM for the EOL-1 AML cell line GNE-987 inhibits cell proliferation and induces apoptosis by promoting the rapid and sustained degradation of BRD4 and inhibiting its downstream targets It also demonstrates potent antitumor activity in AML cell lines
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Cayman Chemical ANTIBODY BI-3406 5mg
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An inhibitor of the K-Ras-SOS1 protein-protein interaction (IC50 = 5 nM); selectively disrupts the protein-protein interaction between K-RasG12C or K-RasG12D with SOS1 over SOS2, and it is selective over 321 kinases in a panel at 10 µM but does inhibit PLK4, BMPR2, and LRRK2 activity by >50%
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Medchemexpress LLC HY-N6687 1mg Medchemexpress, Calcimycin CAS:52665-69-7 Purity:>98%
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Medchemexpress, HY-N6687 1mg Calcimycin CAS:52665-69-7 Calcimycin (A23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). It induces Ca 2+ -dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation of mammalian cells. It induces apoptosis [1] [2] [3] [4] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC CaV1.3 antagonist-1 | 1391385-57-1 | 98.4% | 334.80 | C17H19ClN2O3 | 5 MG
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CaV1.3 antagonist-1 is a potent, selective L-type calcium channel antagonist that preferentially inhibits CaV1.3 with an IC50 of 1.7 μM and >600x selectivity over CaV1.2. The compound is a cyclopentyl pyrimidine-trione derivative described for in vitro studies, including Parkinson's disease research models. Reported purity is approximately 98.4% and it is supplied in solid form and as a DMSO solution.
- Potent CaV1.3 inhibition (IC50 = 1.7 μM).
- High selectivity for CaV1.3 versus CaV1.2 (>600x).
- Suitable for in vitro electrophysiology and cell-based assays.
- Available as solid and as 10 mM solution in DMSO.
- High reported purity (~98.4%) for research use.
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Medchemexpress LLC Sauchinone | 177931-17-8 | MFCD08702698 | 99.9% | 356.37 g/mol | C20H20O6 | 10 MG
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Sauchinone is a diastereomeric lignan isolated from Saururus chinensis that inhibits NF-κB signaling and is used as a research reagent to study inflammatory pathways and related cellular responses. It is provided as a high-purity analytical standard suitable for in vitro assays.
- Inhibits NF-κB signaling and suppresses LPS-inducible iNOS, TNF-α, and COX-2 expression.
- Diastereomeric lignan; molecular formula C20H20O6; molecular weight 356.37 g/mol.
- High purity appropriate for research applications.
- Available in small analytical quantities, including 10 mg pack sizes.
- For research use only; not for human consumption or diagnostic use.
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